从儿童和成年人中获得的类药物的潜力,以研究肠道CYP3A4/5代谢的年龄相关差异

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Eva J Streekstra1, Marit Keuper-Navis2, Jeroen J W M van den Heuvel3

  • 1Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|July 31, 2024
PubMed
概括

类固醇精确地模拟儿童和成人肠道药物代谢 (CYP3A4 / 5),为预测口服药物吸收提供了一个有希望的体外替代新鲜组织.

关键词:
药物代谢酶的药物代谢酶.类药物 (Enteroids) 是一种类型的类药物.肠道有机物 肠道有机物肠道 肠道 肠道儿科 儿科 儿科药理动力学 药理动力学使用室使用室.

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