Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Glomerular Filtration01:15

Glomerular Filtration

1.2K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
1.2K
Renal Corpuscle01:20

Renal Corpuscle

1.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.8K
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

13.2K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
13.2K
Nephrons01:10

Nephrons

2.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.3K
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

2.4K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
2.4K
Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

224
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
224

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Percutaneous Native Kidney Biopsy Complications in Diabetic Patients in the TRIDENT Cohort.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Beyond Genotype: Multidomain Biomarker-Integrated Risk Scores Reveal Prognostic phenotypes Among Individuals with High-Risk <i>APOL1</i> Genotypes.

medRxiv : the preprint server for health sciences·2026
Same author

Thin Glomerular Basement Membrane Phenotypes With No Identified Pathogenic <i>COL4A3/A4/A5</i> Variant.

Kidney international reports·2026
Same author

Podocyte-Targeted Therapy in Focal Segmental Glomerulosclerosis: Insights From a Phase 2 Trial of TRPC6 Inhibition.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Targeting B cells in immune-mediated kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney international·2026
Same author

Communication leading to injury: podocyte-derived fibrillin-1 induces mesangial cell activation and proliferation through EGFR signaling.

Kidney international·2026
Same journal

The Role of Artificial Intelligence in Nephrology Education.

Advances in kidney disease and health·2026
Same journal

Oncohypertension: Unraveling the Link Between Cancer and Hypertension.

Advances in kidney disease and health·2026
Same journal

New Drugs on the Horizon for Hypertension.

Advances in kidney disease and health·2026
Same journal

Hyperammonemia Physiology and Management: A Nephrology-Centered Review.

Advances in kidney disease and health·2026
Same journal

Hypertension in Advanced Chronic Kidney Disease: Saving the Kidneys or the Heart?

Advances in kidney disease and health·2026
Same journal

Social Determinants of Health and Primary Hypertension in Children and Adolescents: Proposed Solutions Using a Socioecological Model of Health.

Advances in kidney disease and health·2026
查看所有相关文章

相关实验视频

Updated: Jun 18, 2025

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

5.6K

焦点细分型淋巴结核硬化症

Varsha Suresh1, Isaac E Stillman2, Kirk N Campbell1

  • 1Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY.

Advances in kidney disease and health
|July 31, 2024
PubMed
概括
此摘要是机器生成的。

焦点细分性淋巴细胞硬化 (FSGS) 涉及损伤和细胞损伤,导致末期病 (ESRD). 了解其各种原因和开发向治疗对于患者的治疗结果至关重要.

关键词:
遗传学 是一个遗传学.细胞是一种细胞.蛋白质尿症是一种蛋白质尿症.

更多相关视频

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

13.6K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

17.6K

相关实验视频

Last Updated: Jun 18, 2025

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

5.6K
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

13.6K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

17.6K

科学领域:

  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 病理学 病理学 病理学
  • 免疫学 免疫学 免疫学

背景情况:

  • 焦点细分性淋巴结核硬化 (FSGS) 是损伤的组织学发现,其特征是某些淋巴结核部分的痕.
  • 这是一种异质的疾病,其原因,临床进展和治疗反应各不相同.
  • 足细胞损伤和损失是FSGS的核心,由主要原因或对脏压力因素的次要反应引起.

研究的目的:

  • 审查目前FSGS的分类,病原和治疗指南.
  • 突出需要更好地了解FSGS病因,特别是免疫因素.
  • 讨论FSGS的新兴和正在研究的治疗策略.

主要方法:

  • 对当前FSGS分类的文献综述.
  • 对 FSGS 中的 podocyte 损伤背后的病理生理机制的分析.
  • 对FSGS的现有和新型治疗方法的检查.

主要成果:

  • 全球范围内,FSGS是末期病 (ESRD) 的主要原因,对健康造成重大负担.
  • 目前对FSGS病原学的理解,特别是免疫学方面的理解,仍然不完整.
  • 需要有针对性的药物开发和先进的治疗方案.

结论:

  • FSGS代表了一种复杂的脏疾病,其中一个统一的特征是细胞损伤.
  • 对各种病因和先进的治疗开发进行进一步的研究对于管理FSGS至关重要.
  • 需要更好的理解和有针对性的治疗来解决FSGS未满足的科学需求.