功能限制预测了心力衰竭的死亡率,其中保留了喷射分数
Domenico Scrutinio1, Pietro Guida2, Andrea Passantino1
1Istituti Clinici Scientifici Maugeri SpA SB, IRCCS, Institute of Bari, Via Generale Nicola Bellomo 73/75, Bari, Italy.
European journal of internal medicine
|July 31, 2024
概括
六分钟步行测试 (6MWT) 距离有效地预测了心力衰竭的死亡率,其中保留喷射分数 (HFpEF) 患者. 在6MWT期间步行较短的距离表明HFpEF中3年全因死亡率的风险明显更高.
科学领域:
- 心脏病学 心脏病学
- 临床医学 临床医学
- 预测 预测 预测 预测 预测
背景情况:
- 六分钟步行测试 (6MWT) 的预后值被确定为心力衰竭与减少喷射率 (HFrEF).
- 有限的数据存在于6MWD和心力衰竭与保存喷射分数 (HFpEF) 的死亡率之间的相关性.
研究的目的:
- 调查6MWT (6MWD) 期间行走的距离与HFpEF患者3年全因死亡率之间的关联.
- 为了确定6MWD是否在HFpEF中提供预后信息.
主要方法:
- 研究了一组482名HFpEF患者的队列,这些患者被录入住院心脏康复中心.
- 主要结局是3年全因死亡率.
- 使用结合已确定的风险标志物的多变量模型来评估6MWD与死亡率之间的关联.
主要成果:
- 在3年的随访期间,174名患者死亡.
- 在6MWD (≤240 m) 最低三分之一的患者,与最高三分之一 (≥360 m) 相比,死亡率的调整危险比率 (HR) (4.94) 显著更高.
- 当对年龄,性别和BMI进行正常化时,预测步行距离百分比的最低三位数 (≤58.1%) 显示出较高的调整HR (3.52) 死亡率.
结论:
- 在6MWT期间行走的距离为HFpEF患者提供了重要的预后信息.
- 通过6MWT评估功能能力对于HFpEF中的风险分层是有价值的.
- 通过6MWD测量较低的功能能力与HFpEF的死亡风险增加有关.
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