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化乙烯甲单体的合成和挑战作为一种策略,用于掩盖树脂复合材料中的水解敏感甲基酸盐群
Michael Lagowski1, Zach Gouveia2, Meilin Yang2
1Institute of Biomedical Engineering, University of Toronto, Ontario, Canada.
防护甲基酸盐 (MA) 牙科复合材料与化组没有改善生物稳定性和负面影响机械性能. 这种方法不建议用于增强牙修复性耐用性.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 聚合物化学 聚合物化学
背景情况:
- 甲基酸盐 (MA) 基牙科修复剂的生物降解会导致通过粘附损失和二次牙导致修复失败.
- 树脂单体中的分子间相互作用会影响复合液解易感性.
- 在MA中掩盖水解敏感的基是改善生物稳定性的潜在策略.
研究的目的:
- 评估MA单体与化基的屏蔽是否增强实验性牙科复合材料的生物稳定性.
- 评估化单体对复合材料性能和耐生物降解性的影响.
主要方法:
- 合成了8种化单体 (FM),并将其纳入实验性树脂复合材料 (FC),其重量为65%.
- 测试了FCs的水相互作用 (接触角度,吸收,凝分数),机械性能 (压缩和屈曲强度/模块) 和细胞相容性.
- 使用模拟人类唾液化酶 (SHSE) 评估了耐生物降解性,并与对照复合物 (CC) 进行了比较.
主要成果:
- 与CC相比,加入FM通常会降低复合材料的物理和机械性能.
- 所有FC在沉浸在SHSE中时都对复合材料的生物降解产生了负面影响.
- 屏蔽MA-引入了分子空间,损害了复合材料完整性所必需的凝聚力.
结论:
- 用化基保护MA- Ester并不是改善牙科树脂复合材料生物稳定的有效策略.
- 这种方法对关键的物理和机械性能产生负面影响.
- 未来的牙科树脂开发应该专注于去除或替换易受伤害的含MAs,而不是屏蔽它们.
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