使用多孔粉和的Hibiscus sabdariffa L.提取物的微封装阿拉伯语:优化过程,表征,稳定性和模拟的胃肠道状况
Román Leyva-López1, Apolonio Vargas-Torres1, Fabiola A Guzmán-Ortiz2
1Centro de Investigación en Ciencia y Tecnología de Alimentos, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo, Av. Universidad Km 1, Rancho Universitario, CP 43600 Tulancingo, Hidalgo, Mexico.
International journal of biological macromolecules
|July 31, 2024
概括
将Hibiscus sabdariffa提取物 (HSE) 封装在多孔的玉米粉-牙阿拉伯语中可以提高稳定性. 优化的喷雾干燥条件保护生物活性化合物,提高其适用于食品和制药应用的可行性.
科学领域:
- 食品科学 食品科学 食品科学
- 材料科学 是一种材料科学.
- 化学工程是化学工程的重要组成部分.
背景情况:
- Hibiscus 提取物 (HSE) 具有显著的抗氧化特性和高的抗生素含量,提供潜在的健康益处.
- 在HSE中的生物活性化合物容易受到环境退化的影响,这限制了它们的应用.
- 微封装是一种有前途的策略,可以提高敏感生物活性化合物的稳定性.
研究的目的:
- 为了优化Hibiscus sabdariffa提取物 (HSE) 的微封装条件,使用混合多孔玉米粉-阿拉伯语系统.
- 在加速老化条件下增强HSE中生物活性化合物的稳定性.
- 评估开发的微封装模型的技术和财务可行性.
主要方法:
- 使用响应表面方法 (RSM) 来优化喷雾干燥参数.
- 优化的关键参数包括入口温度 (IT) 和总固体含量 (TSC).
- 在体外消化模型被用来评估安托素释放率.
主要成果:
- 最佳的微封装条件被确定为126°CIT和8.5%TSC.
- 优化微囊 (OMs) 含有高水平的生物活性化合物: 2368 毫克 GAE / 100g , 694 毫克 QE / 100g 黄,和 930 毫克 EC3G / 100g .
- 在体外消化过程中,OMs在自由HSE (10%) 与HSE (10%) 相比,显著改善了安东素保留率 (40%).
结论:
- 开发的RSM模型为封装HSE.提供了一种可行且具有成本效益的方法.
- 微封装有效地提高了Hibiscus提取物中生物活性化合物的稳定性和受控释放.
- 优化的微囊由于稳定性和生物可用性提高,有可能在食品和制药行业使用.
相关概念视频
Factors Influencing Drug Absorption: Pharmaceutical Parameters
834
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
834
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
733
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
733
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
332
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
332
Production of Organic Acids
105
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
105


