生物时代是否能在患有双相情感障碍的人群中发现加速衰老? 在FACE-BD队列中进行了一项探索性研究
Bruno Etain1,2,3, Cynthia Marie-Claire1, Luana Spano1
1Université Paris Cité, INSERM UMR-S 1144, Optimisation Thérapeutique en Neuropsychopharmacologie OTeN, Paris, France.
Bipolar disorders
|July 31, 2024
概括
少数双相情感障碍患者使用简单的标志物BioAge显示加速衰老. 诸如男性性别,超重和睡眠问题等因素与更快的衰老有关,这表明潜在的干预措施.
科学领域:
- 生物医学研究的研究.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 与预期寿命 (10-15年) 的显著减少有关.
- 现有的加速衰老生物标志物 (例如端粒长度) 的临床适用性有限.
- 需要在常规实践中使用易于获得和具有成本效益的衰老标志物,例如BioAge.
研究的目的:
- 在一大群双相情感障碍患者中计算生物年龄和生物年龄加速 (BioAgeAccel).
- 研究BioAgeAccel与社会人口统计学,临床和药物相关因素之间的关联.
主要方法:
- 使用常规血液检查和体检数据来计算BioAge.
- 生物年龄加速 (BioAgeAccel) 被确定为加速衰老的指标.
- 在2220名患有双相情绪障碍的门诊患者中分析了关联.
主要成果:
- 平均时间年龄为40.2岁,平均生物年龄为39.1岁.
- 一小部分 (15%) 的患者表现出超过2年的BioAgeAccel.
- 更高的BioAgeAccel与年轻的年龄,男性性别,超重和睡眠障碍有关.
结论:
- 通过BioAge测量加速衰老,在双相情感障碍患者的一个子集中观察到.
- 潜在的可改变因素,如较高的BMI和睡眠障碍与加速衰老有关.
- 需要在独立样本中进行复制,与对照组进行比较,并进行纵向研究,以确认发现并探索干预效应.
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