家庭环境中的外虫物种及其抗真菌耐药性概况
Nahid Kondori1,2, Daniel Jaén-Luchoro3,4, Roger Karlsson3,4,5
1Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Box 7193, 402 34, Gothenburg, Sweden. nahid.kondori@microbio.gu.se.
Scientific reports
|July 31, 2024
概括
黑色真菌Exophiala是各种感染的原因,在瑞典的洗碗机中经常检测到. 发现的最常见的物种是Exophiala dermatitidis,突出显示了这种机会性病原体的潜在环境储库.
科学领域:
- 菌类学 菌类学是指菌类学.
- 环境微生物学环境微生物学
- 传染病 传染病 传染病
背景情况:
- 外菌会引起各种各样的感染,从表面感染到侵入性感染,影响免疫力低下和健康的个体.
- 外类物种是囊性纤维化患者常见的呼吸道殖民者,但它们的环境来源和传播途径在很大程度上是未知的.
- 了解Exophiala在环境中的流行对于公众健康至关重要,特别是关于潜在的储库和传播途径.
研究的目的:
- 调查瑞典室内环境中的Exophiala物种的存在和流行情况.
- 为了确定这些环境中常见的特定的Exophiala物种.
- 为了表征孤立的Exophiala菌株的体外抗真菌敏感性.
主要方法:
- 瑞典室内环境的采样.
- 使用基于培养的方法识别Exophiala物种.
- 对各种抗真菌剂进行抗真菌敏感性测试 (MIC确定).
- 分离物的表型特征,包括42°C的生长和酶活性.
主要成果:
- 在洗碗机样本中经常检测到外虫物种.
- 埃克索菲亚拉皮肤炎是最常见的物种,在70%的阳性样本中被发现.
- 几乎所有E. dermatitidis分离物在42°C时都表现出生长,并且具有催化酶阳性.
- 沃里康纳和波萨康纳在体外显示出最低的最小抑制度 (MIC),而乙甘 (caspofungin,anidulafungin) 缺乏显著的抗真菌活性.
结论:
- 洗碗机可以作为Exophiala物种,包括Exophiala dermatitidis的重要环境储存库.
- 单独的E. dermatitidis的高流行率和特殊特征表明它们适应了某些环境条件.
- 需要进一步的研究来阐明Exophiala从环境来源传播到人类的动态.
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