中性细胞细胞外陷调解了斑块微环境和不稳定的动脉斑块形成之间的交叉声
Yu Cao1, Minghui Chen1, Xinyu Jiao2
1Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Experimental & molecular medicine
|July 31, 2024
概括
髓分化蛋白1 (MD-1) 诱导中性粒细胞外细胞陷 (NETs),恶化大脑动脉斑块的不稳定性. 抑制MD-1或NET可以治疗动脉样硬化.
科学领域:
- 心血管生物学 心血管生物学
- 免疫学 免疫学 免疫学
- 分子医学是分子医学.
背景情况:
- 不稳定的动脉动脉样硬化斑与中性粒细胞外细胞陷 (NETs) 有关.
- 网在斑块微环境和不稳定性中的作用机制尚不清楚.
- 这项研究研究了状腺分化蛋白1 (MD-1) 诱导的在状腺斑块不稳定的NETs.
研究的目的:
- 阐明MD-1-诱导NETs在不稳定的斑块形成和斑块微环境之间的交叉声中的作用.
- 了解MD-1如何影响NET形成以及后续对内皮细胞和斑块稳定性的影响.
主要方法:
- 生物信息学分析以识别心动脉不稳定的斑块中的关键基因.
- 使用组织和血样本进行实验验证.
- 评估MD-1水平,NET形成,内皮细胞增殖,迁移和信号通路激活 (托尔类受体,NF-κB).
主要成果:
- 血MD-1升高在患有心血管斑块不稳定的患者中.
- 可溶性MD-1通过Toll-like受体信号传递诱导NET的形成.
- NETs促进内皮细胞的增殖,损害迁移,并激活NF-κB信号,升调炎症标志物 (ICAM1,VCAM1,MMP14,VEGFA,IL6).
- NETs增加了斑块内新血管化,降低了斑块稳定性,并刺激巨细胞产生更多的MD-1,从而创建了一个积极的反循环.
结论:
- 溶解的MD-1触发了NET的产生,导致状腺斑块的不稳定性.
- 网介于斑块微环境和斑块内新血管化之间的交叉声调.
- 抑制NET形成或MD-1分泌是一种潜在的治疗策略,用于不稳定的动脉斑块.
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