HLA进化分歧 (HED) 告知了HLA-B不匹配对 haploidentical 移植后结果的影响
Melhem Solh1, Michael T Aubrey2, Xu Zhang3
1The Blood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA. msolh@bmtga.com.
Bone marrow transplantation
|July 31, 2024
概括
高HLA进化分歧 (HED) 在平分相同的供体移植 (HIDT) 与更糟糕的移植对瘤效应有关,增加复发率. 这一发现影响了HIDT.的供体选择和移植结果.
科学领域:
- 免疫遗传学 免疫遗传学
- 移植免疫学 移植免疫学
- 造血干细胞移植 造血干细胞移植
背景情况:
- 移植与瘤 (GvT) 对移植成功至关重要,通过捐赠者T细胞的介导,通过人类白细胞抗原 (HLA) 识别瘤相关抗原 (TAA).
- 个体的等位基因内的HLA进化分歧 (HED) 影响TAA呈现,但其在平分异性供体移植 (HIDT) 中的作用仍未研究.
研究的目的:
- 研究HED对接受HIDT的患者移植结果的影响.
主要方法:
- 在HIDT中对322个接受者/捐赠者对进行分析,随访时间中位数为57.2个月.
- 对HLA类I和II等位基因对对HED的计算.
- 对HED与无病生存期 (DFS),总生存期 (OS),复发率和非复发死亡率 (NRM) 的相关性的统计分析.
主要成果:
- HLA-B, -DRB1和 -DQB1是平均HED的主要贡献者.
- 在I类中高HED不匹配的接受者/捐赠者单元类型与更糟糕的DFS和更高的复发率相关.
- 特别是在HLA-B单元型中,高HED与更糟糕的OS,DFS和复发增加有关,NRM没有显著差异.
结论:
- 特别是在HLA-B中,HED是影响HIDT结果的重要因素.
- 在不匹配的单元型中增加的HED与较差的移植与瘤疗效有关,导致更高的复发率.
- 这些发现表明,HED可能是HIDT移植成功的预测标志物.
相关概念视频
Tissue Transplantation
352
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
352
Mismatch Repair
4.8K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.8K
Bone Marrow Sampling and Transplants
318
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
318
Cell-mediated Immune Responses
68.0K
Overview
68.0K
Multiple Allele Traits
34.1K
The Concept of Multiple Allelism
34.1K


