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变化的前额外和小脑蛋白神经元计数与雄性大鼠的认知变化有关

Cole King¹, Tessa Maze¹, Bethany Plakke²

¹Psychological Sciences, Kansas State University, 1114 Mid-Campus Dr., Manhattan, KS, 66506, USA.

Experimental brain research

|July 31, 2024

概括

在大鼠中,产前暴露于酸 (VPA) 改变了大脑发育,影响小脑和中部前额皮层的抑制性神经元数量. 这些变化可能会导致自闭症谱系障碍 (ASD) 中出现的认知缺陷.

科学领域:

神经科学是一个神经科学.
发育神经科学的发展神经科学.
自闭症谱系障碍研究研究

背景情况:

产前接触抗发作药物酸 (VPA) 是自闭症谱系障碍 (ASD) 的已知危险因素.
患有自闭症的人通常在小脑和中部前额叶皮层 (mPFC) 呈现结构和功能变化,包括普尔金耶细胞和刺激/抑制平衡的变化.

研究的目的:

为了研究产前VPA暴露对小鼠小脑和mPFC中的抑制性帕瓦胺表达 (PV+) 神经元群体的影响.
评估这些神经生物学变化对年轻成年大鼠认知和焦虑类行为的影响.

主要方法:

在怀孕期间,老鼠暴露于高剂量的VPA.
认知和焦虑类行为被评估使用一个设置转移任务和升高的加迷宫.
在mPFC和特定的大脑小叶 (VI和VII) 中量化了PV+神经元的数量.

主要成果:

暴露于VPA的男性在小脑叶 VII (crus I和II) 中增加了PV+神经元数量,并在mPFC中减少了PV+神经元数量.
暴露于VPA的雄性和雌性大鼠在小脑叶VI中的PV+普金涅细胞数量增加.
在男性中,VI 叶区PV+ 普金涅细胞的增加与维度内转移任务的性能受损相关.

结论:

产前VPA暴露会改变小脑前额回路中的抑制性神经元发育.
在VPA暴露的老鼠中,在六叶片中增加的普金尼细胞增殖可能是观察到的体积变化和认知缺陷的基础.
这些发现表明,这些电路中受阻信号的破坏有助于与ASD相关的认知障碍.

关键词:

自闭症谱系障碍自闭症谱系障碍大脑小部分的大脑小部分中部前额叶皮层中部前额叶皮层.帕尔瓦尔胺是什么?普尔金耶细胞是什么?设置转移 - 设置转移瓦尔酸是一种酸.

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