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相关概念视频

Interphase00:54

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Interphase00:56

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Phases of Interphase
Following each period of mitosis and cytokinesis, eukaryotic cells enter interphase, during which they grow and replicate...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

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Updated: May 12, 2026

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scHiCyclePred:一种深度学习框架,用于从单细胞 Hi-C 数据中预测细胞周期阶段,使用多尺度交互信息.

Yingfu Wu1,2,3, Zhenqi Shi1, Xiangfei Zhou1

  • 1School of Software, Shandong University, Jinan, Shandong, China.

Communications biology
|July 31, 2024
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概括
此摘要是机器生成的。

我们开发了scHiCyclePred,这是一个新的模型,可以使用单细胞Hi-C (scHi-C) 数据准确预测细胞周期阶段. 该工具增强了对3D染色体结构动态的理解,并有助于疾病研究.

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科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 计算生物学 计算生物学

背景情况:

  • 单细胞Hi-C (scHi-C) 技术使得在整个细胞周期中研究3D染色质结构成为可能.
  • 从scHi-C数据准确预测细胞周期阶段是具有挑战性的.

研究的目的:

  • 介绍scHiCyclePred,一种新的预测模型,用于使用scHi-C数据进行细胞周期阶段确定.
  • 为了利用多尺度的3D染色体相互作用特征来提高预测准确性.

主要方法:

  • scHiCyclePred集成了多个功能集,包括多尺度交互信息,以捕获3D染色体结构.
  • 对Nagano_method和CIRCLET进行了比较分析,使用标准指标 (ACC,F1,精度,回忆,BACC).
  • 在复杂的组织数据集 (Liu_dataset) 上进行了评估.

主要成果:

  • 在预测细胞周期阶段方面,scHiCyclePred显著优于现有的方法,如Nagano_method和CIRCLET.
  • 在Liu_dataset上,scHiCyclePred比CIRCLET显著改善: +0.39 (ACC), +0.52 (F1), +0.52 (精度), +0.39 (回忆).
  • 这项研究为细胞周期期间的3D染色质动力学和基因特征提供了新的见解.

结论:

  • scHiCyclePred提供了一种可靠的方法,可以从scHi-C数据中预测细胞周期阶段.
  • 该模型增强了对细胞循环依赖的染色质组织的理解.
  • 这些发现对细胞生物学和疾病研究有影响,该工具可在GitHub上找到.