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Updated: Jun 18, 2025

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在腺A2A受体中平衡G蛋白选择性和有效性

Louis-Philippe Picard1, Alexander Orazietti2, Duy Phuoc Tran3

  • 1Department of Chemical and Physical Sciences, University of Toronto Mississauga (UTM), Mississauga, Ontario, Canada. louisphilippe.picard@utoronto.ca.

Nature chemical biology
|July 31, 2024
PubMed
概括

氨酸A2A受体 (A2A R) 使用两个不同的TM6状态来结合不同的G蛋白. 然后,TM7动态控制了这些G蛋白激活的有效性,从而影响了信号传递的有效性.

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