边缘宽度和局部复发在患有乳腺细胞瘤的患者
Haydee Del Calvo1, Yun Wu2, Heather Y Lin3
1Department of Surgery, Houston Methodist Hospital, Houston, TX, USA.
Annals of surgical oncology
|July 31, 2024
概括
对于良性乳腺类瘤 (PTs),瘤上没有墨水的边缘足够. 然而,对于边缘性或恶性PT,更广泛的外科手术边缘对于降低局部复发风险至关重要.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 乳房手术 乳房手术
背景情况:
- 对于乳腺的乳腺瘤 (PTs) 的手术边缘宽度有争议.
- 评估保证金对长期局部复发 (LR) 风险的影响至关重要.
研究的目的:
- 评估外科手术边缘宽度对乳腺瘤中局部复发风险的影响.
- 确定不同PT亚型的最佳利准则.
主要方法:
- 对117名经证实PT患者 (2008-2015年) 的回顾性审查.
- 边缘被分类为积极的,狭窄的 (<10mm) 或广泛自由的 (>=10mm).
- 使用卡普兰-梅尔法分析的局部复发率.
主要成果:
- 积极和狭窄的利与与广泛的自由利相比,与显著更高的LR风险有关.
- 对于良性PTs,10年LR无病率为100% (广泛无病),94% (狭窄) 和66% (阳性).
- 对于边缘性/恶性PTs,10年无LR率为93% (广泛无) 和57% (狭窄),狭窄的边缘显示与积极边缘相比的LR.
结论:
- 对于良性PTs,实现"没有瘤上的墨水"是足以进行局部控制的.
- 对于边缘性或恶性PT,建议使用更宽的外科边缘 (>=10mm) 来最大限度地降低LR风险.
- 侵袭性PT亚型中狭窄的边际与类似于正边际的复发率相关.
相关概念视频
01:30Skin Cancer
4.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.0K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K