基线液体局部化对1型黄斑新血管化治疗抗VEGF治疗视力敏度和预后的影响
Etienne Gadiollet1, Laurent Kodjikian1,2, Fanélie Vasson3
1Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
Eye (London, England)
|July 31, 2024
概括
在1型黄斑新血管化 (MNV) 中,内液 (IRF) 表明视觉结果较差,缩和纤维化率较高,而仅与下液 (SRF) 相比. 这一发现对于管理与年龄相关的黄斑变性 (AMD) 是至关重要的.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 与年龄相关的斑点退化 (AMD)
背景情况:
- 1型黄斑新血管化 (MNV) 是与年龄相关的黄斑退化 (AMD) 中视力丧失的主要原因.
- 了解液体局部化的预后价值对于指导治疗策略至关重要.
- 视网下液 (SRF) 和视网内液 (IRF) 是疾病活动的关键指标.
研究的目的:
- 评估1型与AMD相关的MNV中子液 (SRF) 和内液 (IRF) 的预后意义.
- 根据流体的存在和位置来比较视觉结果.
主要方法:
- 对211个未接受过治疗的眼睛进行前性研究,这些眼睛因AMD而患有1型MNV.
- 眼睛接受了24个月的抗血管内皮生长因子 (抗VEGF) 静脉内注射.
- 眼睛被分为单独的SRF或IRF (有或没有SRF) 组.
主要成果:
- 基线内耳液 (IRF) 与12个月和24个月的最佳校正视敏度 (BCVA) 的降低有关 (p<0.001).
- 只有SRF的眼睛显示出比IRF (56.9个字母) 的眼睛更好的视觉结果 (12个月的BCVA:74.3个字母).
- 基线IRF预测24个月后纤维化 (p=0.03) 和缩 (p<0.001) 的比率增加.
结论:
- 在1型MNV中基线IRF的存在与单独SRF相比,与较差的视觉预后有关.
- IRF存在与视网膜缩和纤维化发生率较高相关.
- 流体局部化是预测1型MNV的AMD患者的结果的一个重要因素.
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