在儿科小管间性炎和脑膜炎综合征 (TINU) 中的临床结果
Mallory Mandel1, Abdelrahman M Elhusseiny2,3, Stefanie L Davidson4
1Department of Nephrology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Eye (London, England)
|July 31, 2024
概括
在儿童中,管介质炎和脑膜炎综合征 (TINU) 通常需要除类固醇外的免疫调节治疗 (IMT),许多需要生物药物. 早期的尿液分析和功能测试对于在儿科紫外炎病例中诊断TINU至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 儿科 儿科 儿科
背景情况:
- 管介质炎和脑膜炎综合征 (TINU) 是一种罕见的疾病,影响眼睛和脏.
- 了解儿科患者的临床过程和治疗结果对于有效管理至关重要.
研究的目的:
- 评估儿童患者中TINU的临床表现,病程和治疗结果.
- 确定与治疗需求和疾病复发相关的因素.
主要方法:
- 一个多中心的回顾性队列研究包括110名患者 ≤21年被诊断患有TINU.
- 诊断需要紫外线炎,血清肌素 (SCr) 升高,尿液分析异常或尿液β2-微球蛋白 (β2M) 升高.
- 用单变量和多变量方法分析了临床表现,治疗和结果的数据.
主要成果:
- 患者的中位年龄为13岁,90%的患者有症状性脑膜炎,主要是双侧前脑膜炎 (94%).
- 84%需要免疫调节疗法 (IMT),其中甲甲酸盐和甲酸是常见的第一线药物; 45%需要生物药物.
- 尿道炎复发 (53%) 比炎复发 (16%) 更常见. 炎在90%的患者中得到控制,而尿膜炎在74%的患者中得到控制.
结论:
- 大多数儿科TINU患者需要使用类固醇节省的IMT,通常包括生物药物,以控制脑膜炎.
- 尿液分析,尿液β2M和SCr测试是推给患有膜炎的儿童,特别是双边前部病例,以帮助TINU诊断.
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