骨髓缩作为长期COVID综合征的表现:系统性审查
P Za1,2, G F Papalia3,4, P Gregori1,2
1Department of Orthopaedic and Trauma Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy.
COVID-19 感染可能导致过早骨 necrosis (ON),即使在较低的皮质类固醇 (CCS) 剂量. ON症状与长期COVID时间表一致,表明存在潜在联系,并强调需要对有SARS-CoV-2感染史和CCS使用史的患者保持警.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- 在SARS-CoV-2感染后持续出现的症状被称为长期COVID综合征.
- 报道了几例COVID-19后的骨 necrosis (ON) 的情况.
- 需要进一步调查SARS-CoV-2和ON之间的关系.
研究的目的:
- 为了调查SARS-CoV-2感染和骨硬化之间的潜在相关性.
- 为了确定骨髓缩是否可以被归类为长期COVID的组成部分.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 包括的研究涵盖了所有证据水平,不包括那些没有皮质类固醇 (CCS) 规范或与COVID-19无关的研究.
- 提取的数据包括患者人口统计,临床表现,成像发现,治疗细节和结果.
主要成果:
- 该审查包括13项研究,涉及95名患者和159个受影响的关节.
- 骨髓缩症状在COVID-19诊断后大约16周出现,MRI在症状出现6周后进行.
- 患者在20.6天内平均接受了926.4毫克的普雷迪尼索隆相当剂.
结论:
- 患有COVID-19病史的患者早些时候和较低的皮质类固醇剂量比通常观察到的更早地发生骨质死.
- 骨髓缩症状的发生时间属于长期COVID时期.
- 外科医生必须考虑在报告在SARS-CoV-2感染和皮质类固醇治疗后持续关节疼痛的患者骨髓缩.
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