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缓解倍数,少是多:检查辅助生殖技术多胎妊娠率的趋势

Hanna Kim¹, Andrew J Claffey², Kevin J Doody^3,4

¹Cleveland Clinic Foundation OB/GYN and Women's Health Institute, Reproductive Endocrinology and Infertility, Cleveland, OH, USA.

Journal of assisted reproduction and genetics

|July 31, 2024

概括

辅助生殖技术 (ART) 显示多胎妊娠 (MFG) 率下降,双胞胎出生较少,但在十多年的自主试管婴儿周期中,活产率 (LBR) 也较低.

科学领域:

生殖医学生殖医学
不孕症研究不孕症研究
围产期统计数据围产期统计数据

背景情况:

多胎妊娠 (MFG) 是一种已知的辅助生殖技术 (ART) 的并发症.
了解MFG和活产率 (LBR) 的趋势对于优化ART结果至关重要.
近几十年来,ART实践发生了变化,包括胚胎移植政策.

研究的目的:

分析过去十年在辅助生殖技术 (ART) 中多胎妊娠 (MFG) 率的变化.
评估这些变化对自主周期中活产率 (LBR) 的影响.
确定胚胎移植实践的趋势及其与妊娠结果的相关性.

主要方法:

使用辅助生殖技术协会 (SART) 国家总结报告 (2014-2020) 的回顾性队列研究.
分析的重点是自律周期,分母年龄组分层 (<35,35-37,38-40,41-42,>42).
用描述性统计和双尾T测试来确定趋势和统计学意义.

主要成果:

从2014年到2020年,在所有年龄组中,在自生胚胎移植中观察到双胞胎出生率大幅下降.
在研究期间,自身体外受精 (IVF) 周期的总体活产率 (LBR) 在所有年龄组中也以相似的速度下降.
转移的胚胎的平均数量显著下降,特别是在42岁以下的妇女中.

结论:

多胎妊娠 (MFG) 率的下降,包括双胞胎和更高阶出生,与选择性单个胚胎移植 (eSET) 和植入前遗传测试 (PGT) 的采用增加相关.
不孕不育的根本原因并没有对多胎妊娠率产生重大影响.
人工智能技术的实践已经进化,导致减少多胎妊娠,但同时也减少了活产率.

关键词:

选择性单个胚胎移植选择性单个胚胎移植在试管婴儿受精体外受精.活生生的出生率是多少多个胎儿怀孕的时间.他们是双胞胎,双胞胎.

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