夜班工作和女性乳腺癌:为正确的风险定义而进行两阶段剂量反应元分析
Jinyoung Moon1,2, Atsuko Ikeda-Araki3,4, Yongseok Mun5
1Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul, 08826, South Korea.
BMC public health
|July 31, 2024
概括
夜班工作增加了女性患乳腺癌的风险. 这种剂量反应元分析发现,夜班暴露的更长时间与乳腺癌风险增加之间存在显著的关联.
科学领域:
- 流行病学 流行病学
- 职业健康 职业健康 职业健康
- 在瘤学瘤学.
背景情况:
- 夜班工作在全球普遍存在,影响着数百万个人.
- 以前的研究表明,夜班工作与女性乳腺癌风险增加之间存在潜在联系.
- 然而,需要进行全面的剂量反应分析来准确量化这种风险.
研究的目的:
- 进行高质量的,两阶段的剂量反应元分析.
- 调查夜班工作暴露时间与女性乳腺癌风险之间的关系.
主要方法:
- 在PubMed,EMBASE和Cochrane图书馆进行了系统的文献搜索.
- 严格应用纳入标准来选择相关的队列和病例控制研究.
- 使用可靠的剂量反应元分析方法,将风险比率 (RRs) 和赔率比率 (ORs) 结合起来.
主要成果:
- 包括10项队列研究 (15,953例) 和11项病例控制研究 (9,196例).
- 对于队列研究,30年的夜班暴露显示了1.1328 (95% CI 1.0419-1.2317) 的综合风险比率.
- 对于病例控制研究,30年的暴露产生了1.8817 (95% CI 1.3784-2.5687) 的合并几率比率.
结论:
- 这种剂量反应元分析提供了强有力的证据,证明长时间夜班工作与女性乳腺癌风险增加有关.
- 这些发现强调了在癌症预防策略中考虑职业暴露的重要性.
- 进一步的研究应该集中在生物机制和夜班工人的保护措施上.
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