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美国成年人中的METS-IR/HOMA-IR和MAFLD:剂量反应相关性和体力活动介导的影响

Hongye Peng^1,2, Jingjing Xiang³, Liang Pan⁴

¹Department of Infection, Guang'anmen Hospital, , China Academy of Chinese Medical Sciences, Beijing, China. 20190931732@bucm.edu.cn.

BMC endocrine disorders

|July 31, 2024

概括

胰岛素抵抗的代谢评分 (METS-IR) 和胰岛素抵抗的恒温模型评估 (HOMA-IR) 与脂肪肝疾病风险有关. 身体活动部分调解了这种关联,这表明生活方式的改变可能有助于管理MAFLD.

科学领域:

代谢健康代谢健康
肝脏疾病研究肝脏疾病研究
公共卫生公共卫生

背景情况:

与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一种普遍的疾病,与胰岛素抵抗 (IR) 密切相关.
身体活动 (PA) 在MAFLD和IR中发挥作用,突出了潜在的生活方式干预措施.

研究的目的:

探索METS-IR和HOMA-IR与MAFLD之间的剂量反应关系.
研究PA在IR标志物与MAFLD之间的关联中的调解作用.

主要方法:

对NHANES参与者的横截面分析.
逻辑回归和ROC曲线用于评估METS-IR/HOMA-IR对MAFLD的预测性能.
限制性立方线用于剂量反应可视化和决策树分析,用于识别高风险子组.

主要成果:

在METS-IR和HOMA-IR与MAFLD风险之间发现了积极的关联 (OR=1.162和1.630).
与HOMA-IR相比,METS-IR对MAFLD的预测性能更好 (AUC=0.831对0.767).
身体活动介于METS-IR/HOMA-IR和MAFLD之间的约0.81%和0.78%的关联.

结论:

METS-IR和HOMA-IR可以预测MAFLD风险,而METS-IR表现更好.
身体活动部分调解了红外线标志物和MAFLD之间的关系.
专注于体育活动的生活方式修改可能对管理MAFLD至关重要.

关键词:

在HOMA-IR中,你会看到HOMA-IR.马夫尔德 (MAFLD) 是一个这就是METS-IR的意义.调解效应是一种调解效应.身体活动身体活动

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