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0.05%阿特罗眼滴对近视的进展和外围失焦的频率依赖性影响:一项前性研究
Yuanfang Yang1, Minsong Xue1, Jiangdong Hao1
1Aier School of Ophthalmology, Central South University, Changsha, 410015, China.
Eye and vision (London, England)
|July 31, 2024
概括
低剂量阿特罗平眼药减缓了儿童近视的进展. 每日使用是最有效的,但即使是每周使用也会影响外周折射,随着时间视网膜变化与进展缓慢相关.
科学领域:
- 眼科医生 眼科 眼科
- 儿科光学测量 儿科光学测量
- 控制近视 控制近视
背景情况:
- 0.05%的阿特罗宾眼药在减缓近视的进展方面是有效的.
- 这项研究研究了近视儿童的外周折射 (PR),使用0.05%的多氨酸在不同的频率.
研究的目的:
- 为了评估不同0.05%的氨酸眼滴频率对近视儿童外周折射的影响.
- 要了解热素频率,近视的进展和周围折射误差的变化之间的关系.
主要方法:
- 一项为期一年的前性研究,涉及138名近视儿童,随机分配每天一次 (7/7),每周两次 (2/7),或每周一次 (1/7) 的阿特罗宾治疗.
- 测量包括使用哈特曼-沙克波面传感器的球形等价 (SE),轴长 (AL) 和外围折射 (PR).
- 相对外围折射率 (RPR) 是通过从外围测量中减去中心来计算的.
主要成果:
- 与每天 (7/7) 和每周两次 (2/7) 组相比,每周一次 (1/7) 组的SE增加和AL延长显著增加.
- 1/7组在叶和上,下和鼻子视网膜中表现出更多的近视PR,而在外围则较少近视RPR.
- 7/7组在整个视网膜中显示近视RPR转移,而1/7组在上层视网膜中显示高视RPR转移;时间RPR近视转移与近视进展较少相关.
结论:
- 氨酸以频率依赖的方式抑制近视的进展,每日使用最有效.
- 虽然每日的阿特罗平 (7/7) 最能减缓进展,但它会在RPR中诱导更多的近视转移.
- 在所有治疗组中,视网膜的相对外周折射与近视的进展有关.
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