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在中等水平的立陶宛医院中,药物错误的高患病率:一项前性横截面观察性研究
J Butauskaite1, A Zumbakyte1, L Aukstikalne2
1Medical Academy, Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Pharmacology research & perspectives
|August 1, 2024
概括
在服用多种药物的老年患者中发现了高患病率的药物错误 (ME). 多药学与ME的增加有显著的相关性,强调需要更好的处方实践和医生教育.
科学领域:
- 老年医学 老年医学
- 临床药房 临床药房
- 患者安全 患者安全
背景情况:
- 人口老龄化导致慢性疾病和多药性疾病的增加.
- 多药,加上肥胖和器官功能障碍等因素,提高了药物错误 (ME) 的风险.
- 现有的关于ME在特定医院部门的患病率的数据有限.
研究的目的:
- 为了确定药物错误 (ME) 在内科,心脏病学和神经病学部门的患病率.
- 调查多药与ME发生之间的相关性.
- 确定导致ME的患者特异性风险因素.
主要方法:
- 一项前性观察性研究,涉及145名住院患者.
- 分析电子/纸质处方和药物动力学风险因素 (脏/肝功能,体重,年龄).
- 统计分析包括斯皮尔曼相关性,以评估药物数量和ME之间的关系.
主要成果:
- 在91.7%的患者 (133/145) 中观察到ME的高患病率,超过了50%的假设.
- 每名患者处方药物的中位数为8.
- 在处方药的数量和ME的数量之间发现了中度的正相关性 (斯皮尔曼的 ρ = 0.428,p < .001).
结论:
- 该研究显示,在研究的医院部门中,药物错误的流行率显著高.
- 多药性是导致药物错误的一个关键因素,需要谨慎的处方管理.
- 对医生的持续教育和系统的处方评估对于改善患者安全和合理治疗至关重要.
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