在2型糖尿病中,通过动态脏扫描评估的1,5-无糖醇和功能之间的关系
Jiaying Ni1, Hang Su1,2, Yaxin Wang1
1Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
The Journal of clinical endocrinology and metabolism
|August 1, 2024
概括
血清1,5-基醇 (1,5-AG) 显示在2型糖尿病中与功能有很弱的反向相关性. 然而,1,5-AG仍然是葡萄糖控制的可靠指标,即使是轻度至中度功能障碍.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
背景情况:
- 作为2型糖尿病患者的血糖标志物,血清1,5-基醇 (1,5-AG) 的可靠性在功能不全患者中仍在争论中.
- 功能显著影响各种生物标志物的解释.
研究的目的:
- 研究2型糖尿病中测量的球透率 (mGFR) 和血清1,5-AG水平之间的关系.
- 为了确定功能对1,5-AG作为血糖控制指标的准确性的影响.
主要方法:
- 分析了5337名2型糖尿病患者.
- 通过99mTc-DTPA动态脏扫描测量球过率 (mGFR) 来评估功能.
- 参与者根据mGFR水平分为五组.
主要成果:
- 在mGFR和血清1,5-AG (r = -0.189,P <.001) 之间观察到一个弱而具有统计意义的逆相关性.
- mGFR独立预测了血清1,5-AG水平,即使在对HbA1c进行调整后.
- 1,5-AG和血糖标记之间的相关性对于mGFR≥30mL/min/1.73m2仍然显著,但在较低的GFR水平下减弱.
结论:
- 血清1,5-AG在2型糖尿病中显示出与mGFR的弱反相关性.
- 尽管存在这种相关性,但1,5-AG被认为是评估轻度至中度功能障碍患者血糖控制的有效标志物.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
69
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
69
01:23Renal Clearance
824
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
824
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
102
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
102