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麻症是淋巴瘤患者的预后因素:系统性审查和元分析

Yixuan Li¹, Qi Sheng², Jiayao Li³

¹Department of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Leukemia & lymphoma

|August 1, 2024

概括

肌肉消耗性疾病 - - 萨科佩尼亚与淋巴瘤患者无进展生存率的恶化有关. 虽然对整体存活率的初步发现受到偏差的影响,但小组分析显示,肉症对血造细胞移植后和男性患者的存活率产生负面影响.

科学领域:

在瘤学瘤学.
老年病的医生老年病的医生
肌肉生理学肌肉生理学

背景情况:

肉类和淋巴瘤预后之间的关系尚不清楚,现有研究显示结果不一致.
标志着肌肉质量和功能丧失的萨科佩尼亚可能会影响癌症的结果.

研究的目的:

在淋巴瘤患者中,系统地调查肉类和生存结果之间的关联.
分析萨科佩尼亚对淋巴瘤总生存期 (OS) 和无进展生存期 (PFS) 的影响.

主要方法:

在Embase,Science Direct,Cochrane Library和PubMed数据库中进行了系统的文献搜索,截至2024年3月31日.
在两个研究人员进行独立提取和评估后,包括了26项涉及3659名参与者的研究.
进行了元分析,将OS和PFS的危险比率 (HRs) 汇集起来,并进行子组分析和出版偏差评估.

主要成果:

麻性淋巴瘤患者最初显示较差的OS (HR = 1.88),但在调整出版偏差后,这变得无意义.
萨科佩尼亚与更糟糕的PFS (HR = 1.77) 有关,没有显著的出版偏差.
亚组分析显示,在输血细胞移植 (HCT) 后,萨科佩尼亚是OS的负预测因素 (HR = 1.61),在男性淋巴瘤患者 (HR = 2.29) 和初级中枢神经系统淋巴瘤 (PCNSL) 患者 (HR = 2.20).

结论:

麻症与淋巴瘤患者的无进展生存率恶化有关.
在特定的亚组中,萨尔科佩尼亚负面预测整体存活率,包括 HCT 后,男性患者和 PCNSL 患者 (由 TMT 定义).
需要进一步的研究来澄清萨科佩尼亚在淋巴瘤中的预后作用,考虑到不同的定义和患者群体.

关键词:

萨尔科佩尼亚是什么意思萨尔科佩尼亚这项研究已在PROSPERO (CRD 42020158269) 中注册.淋巴瘤淋巴瘤是什么死亡率死亡率总体存活率总体存活率系统审查和元分析.

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