福克斯M1通过促进自细胞通过促进骨髓瘤细胞中介于甲基酸耐药性
Luoyang Wang1, Dongchang Zhai2, Lei Tang2
1Department of Immunology, School of Basic Medicine, Qingdao University, Qingdao 266071, China.
Acta biochimica et biophysica Sinica
|August 1, 2024
概括
转录因子FOXM1通过增强自性来驱动骨髓瘤中的甲状腺抗性. 准FOXM1或自可能会改善这种骨癌的化疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 骨髓瘤 (OS) 是一种主要影响青少年和老年人的骨癌.
- 目前的OS治疗严重依赖于化疗,但耐药性严重阻碍治疗成功.
- 转录因子FOXM1涉及各种癌症过程,包括耐药性,但其在OS中甲状腺素耐药性的作用尚未被探索.
研究的目的:
- 调查FOXM1在骨髓瘤中对甲状腺酸盐 (MTX) 耐药性的作用.
- 阐明FOXM1介导的MTX抗性的潜在分子机制.
主要方法:
- 在OS组织和MTX耐药细胞中评估FOXM1表达.
- 研究了FOXM1过度表达和沉默对MTX敏感性的影响.
- 研究了自的作用,特别是HMMR/ATG7通路在FOXM1诱导的MTX耐药性中的作用.
主要成果:
- 在OS组织和MTX耐药细胞中,FOXM1的表达很高,与MTX耐药性相关.
- 过度表达FOXM1通过增强自以HMMR/ATG7依赖的方式促进MTX耐药性.
- 沉默FOXM1或抑制自可以有效地逆转OS细胞中的MTX抵抗.
结论:
- 在骨髓瘤中,FOXM1在赋予MTX耐药性方面发挥着关键作用.
- 福克斯M1通过一种自依赖的途径增强MTX耐药性,涉及HMMR/ATG7.
- 准FOXM1或自途径是一个潜在的治疗策略,以克服OS中的MTX抵抗.
更多相关视频
09:40Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
2.6K
11:15A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.2K
相关概念视频
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
01:22PI3K/mTOR/AKT Signaling Pathway
3.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.5K
01:27Autophagy
4.2K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.2K