肝细胞癌中的代谢重编程:从2011年到2023年进行的文献计量和可视化研究
Xia Li1, Liping Zhou1, Xinyi Xu1
1School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in pharmacology
|August 1, 2024
概括
这项研究分析了575篇关于肝细胞癌 (HCC) 代谢重编程的出版物. 研究趋势显示,转向综合代谢和瘤微环境相互作用,指导未来的HCC研究.
科学领域:
- 在瘤学瘤学.
- 代谢研究研究 代谢研究
- 图书统计学 图书统计学
背景情况:
- 代谢重编程是癌症的标志,特别研究了肝细胞癌 (HCC).
- 由于其高发病率和死亡率,了解HCC的代谢机制至关重要.
- 这项研究提供了对HCC代谢重编程研究的科学度分析.
研究的目的:
- 确定肝细胞癌 (HCC) 代谢重编程的研究热点和边界.
- 为未来关于HCC代谢的科学研究和决策提供指导.
- 绘制HCC代谢研究的协作格局和不断变化的趋势.
主要方法:
- 从Web of Science Core Collection (WoSCC) 数据库中对575个出版物的图书统计分析 (截至2023年11月).
- 在R中使用文献计量工具进行科学计量分析和可视化.
- 分析了关键词,作者,组织,国家,期刊和引用数据.
主要成果:
- 对HCC代谢重编程的研究显示,HCC的年增长率为39.11%,其中中国和美国是领先的国家.
- 关键的研究主题包括糖解,瘤微环境,华堡效应,线粒体和缺氧.
- 富丹大学和王杰,李和杰等作者是著名的;Ally A在Cell上的论文得到了最多的引用.
结论:
- 研究已经从单个代谢途径演变为综合代谢和瘤微环境相互作用.
- 瘤微环境和代谢重编程之间的动态代表了未来的研究方向.
- 结果为HCC预防,治疗策略和未来的研究工作提供了洞察力.
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