细胞:在与癌症相关的炎症方面,万事通
Marianna Moro1, Federica Carolina Balestrero1, Ambra A Grolla1
1Department of Pharmaceutical Sciences, Università del Piemonte Orientale, Novara, Italy.
Frontiers in pharmacology
|August 1, 2024
概括
细胞是关键的壁细胞,在癌症中与免疫细胞相互作用. 本综述强调了它们在瘤生长,侵袭和转移中的作用,并讨论了针对血管正常化和免疫治疗的治疗方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
背景情况:
- 细胞,传统上被视为支持内皮细胞 (ECs) 的壁细胞,在组织和器官功能中具有多方面的作用.
- 新出现的证据揭示了皮细胞根据细胞相互作用调整其功能的能力,并对促炎性刺激做出反应.
- 细胞积极与免疫细胞接触,影响它们的转移和调节免疫反应,通常促进癌症中的免疫抑制.
研究的目的:
- 审查瘤微环境中的细胞和免疫细胞之间的复杂相互作用.
- 阐明皮质细胞对原发性瘤生长,恶性细胞入侵和转移前位形成的贡献.
- 探索用于血管正常化和增强癌症免疫疗法疗效的药理学策略.
主要方法:
- 文献综述专注于癌症中的细胞周细胞-免疫细胞相互作用.
- 对瘤动态,入侵和转移中的细胞周细胞参与的证据的分析.
- 探索针对血管正常化和免疫治疗的当前和新兴治疗方法.
主要成果:
- 细胞是瘤进展的关键参与者,影响瘤质量动态,促进恶性细胞的入侵和迁移.
- 细胞有助于形成前转移性,支持癌症的传播.
- 细胞可以维持一种免疫抑制的表型,影响抗瘤免疫力.
结论:
- 细胞在癌症中表现出动态的作用,超出血管支持范围,积极塑造瘤微环境和免疫反应.
- 准细胞周细胞功能和血管正常化为癌症治疗提供了有前途的治疗途径.
- 涉及血管正常化和免疫治疗的联合策略有可能改善癌症治疗结果.
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