错过的机会:关于为什么非职业性艾滋病毒暴露后预防不充分利用的叙述性审查
Lao-Tzu Allan-Blitz1,2, Kenneth H Mayer3,4,5,2
1Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Open forum infectious diseases
|August 1, 2024
概括
暴露后预防 (PEP) 对于预防艾滋病毒至关重要,但未得到充分利用. 由于意识,获取和耻辱问题,许多符合条件的个人没有获得PEP,突出了需要改进的领域.
科学领域:
- 公共卫生 公共卫生
- 预防传染病 预防传染病
- 艾滋病毒/艾滋病研究研究
背景情况:
- 暴露后预防 (PEP) 是预防艾滋病毒感染的关键干预措施.
- 尽管PEP具有重要意义,但在全球范围内,它仍未得到充分利用.
- 了解不足利用的原因是改善获取和有效性的关键.
研究的目的:
- 在全球范围内审查错过的PEP处方机会的频率.
- 探索阻碍PEP提供和普及的复杂挑战.
- 识别和描述增强PEP实施的潜在解决方案.
主要方法:
- 在过去10年内发表的20项研究的叙述性综述.
- 分析包括了来自43,832个人的数据,估计有41,477人有资格获得PEP.
- 在不同的护理环境中比较PEP处方率.
主要成果:
- 在审查的研究中,PEP被规定给66.8%的符合条件的个人.
- 在急性 (63.5%) 和非急性 (94.5%) 护理环境之间观察到PEP处方的显著差异.
- 确定的主要障碍包括缺乏提供者/患者意识,接受度低,艾滋病污名,接入问题和污名化政策.
结论:
- 解决提供者和患者的意识对于增加PEP利用至关重要.
- 提高PEP的接受度和打击艾滋病毒污名对于有效实施至关重要.
- 除了政策改革之外,提高获得护理和药物的机会,将改善PEP的提供.
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