营养状况会影响免疫功能,并加剧肺结核病的严重程度
Chunli Lu1, Yunyi Xu2, Xueya Li2
1Department of Clinical Nutrition, Guangzhou Chest Hospital, Guangzhou, China.
Frontiers in immunology
|August 1, 2024
概括
营养状况和免疫功能显著影响肺结核病 (PTB) 的严重程度. 保持良好的营养和免疫健康,以及监测血小板与淋巴细胞比率 (PLR),可以降低严重的PTB风险.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 肺结核 (PTB) 的严重程度受到各种宿主因素的影响.
- 了解营养状况和免疫功能之间的相互作用对于管理PTB至关重要.
- 在活跃的PTB患者中,营养缺乏和免疫失调是常见的.
研究的目的:
- 调查营养状况,免疫功能和肺结核病的严重程度之间的关联.
- 确定免疫功能是否介导营养状况对PTB严重性的影响.
- 为了确定预测PTB严重程度的潜在生物标志物.
主要方法:
- 一项对952名活跃PTB患者进行的描述性横截面研究.
- 通过BMI,NRS-2002,TP,PA,TRF,ALB和PNI评估的营养状况.
- 通过CD4+计数,CD4+/CD8+比率,NLR和PLR评估的免疫功能.
- 使用多变量逻辑回归,通用线性回归和调解分析.
主要成果:
- 严重的PTB与老年,男性性别,糖尿病,更高的营养风险,免疫功能障碍和较低的淋巴细胞数量有关.
- 对于PTB严重性的保护因素包括BMI和PNI;PLR是一个危险因素.
- 免疫功能障碍和PLR调解了营养状况和PTB严重程度之间的关系.
- 将BMI,PNI和PLR与临床指标的联合使用显示出有希望的诊断价值 (AUC=0.701).
结论:
- 营养状况与PTB严重程度有很大关系.
- 免疫功能在营养状况和PTB严重程度之间的关系中起到调解作用.
- 保持适当的营养状况 (BMI,PNI) 和免疫功能,同时降低PLR,可以减轻严重的PTB风险.
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