人类心血管疾病中的肠道透性:系统性审查和元分析
Jiang-Hong Xiao1, Yu Wang1, Xi-Mei Zhang1
1Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an, China.
Frontiers in nutrition
|August 1, 2024
概括
心血管疾病与肠道透性增加有关. 这一元分析证实了心血管疾病患者的肠道屏障受损,这表明了潜在的诊断和治疗标志物.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 生物标志物 生物标志物
背景情况:
- 心血管疾病和肠道透性之间存在联系,但需要进一步澄清.
- 肠道透性是指肠道屏障控制物质通过的能力.
- 了解这种关系对于心血管疾病管理至关重要.
研究的目的:
- 阐明肠道透性和心血管疾病之间的关系.
- 进行现有研究的定量元分析.
- 为了确定潜在的生物标志物用于心血管疾病的诊断和治疗.
主要方法:
- 在2023年4月之前,对多学科电子数据库进行了系统搜索.
- 包括的研究被评估为偏见的风险使用乔安娜·布里格斯研究所的批判性评估清单.
- 数据使用Review Manager 5.3和Stata 16.0进行分析,以I2统计学来评估异质性.
主要成果:
- 包括13项研究,涉及1321名受试者 (大多数年龄大于48岁).
- 与对照组相比,患有心血管疾病的患者表现出显著更高水平的肠道透性标记物.
- 升高的标记物包括脂多糖,d-乳酸盐,佐努林和血清二胺氧化酶.
结论:
- 分析证实了心血管疾病患者的肠道屏障损伤和肠道透性增加.
- 特定的肠道透性标记物显示出诊断和治疗心血管疾病的潜力.
- 对这些标记物的进一步研究可以促进心血管医学的发展.
相关概念视频
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
160
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
160
01:17Chronic Bowel Disorders: Introduction
436
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
436
01:23Assessment of the Cardiovascular System I: Subjective Data
293
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
293