研究血清维生素B12水平与不育男性异常DNA甲基化之间的相关性
Dharmendra Kumar1, Neeraj K Agrawal1
1Department of Endocrinology and Metabolism, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh, India.
Indian journal of endocrinology and metabolism
|August 1, 2024
概括
类精子不育的雄性表现出显著较低的维生素B-12水平. 虽然全球DNA甲基化没有显著差异,但这项研究发现维生素B-12和男性不孕症中DNA甲基化之间没有相关性.
科学领域:
- 生殖生物学 生殖生物学
- 营养生物化学 营养生物化学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 变化的精子DNA甲基化与男性不孕症和精液质量差有关.
- 维生素B-12影响1碳代谢,可能影响DNA甲基化模式.
研究的目的:
- 研究血清维生素B-12水平与不育男性异常DNA甲基化之间的关联.
- 为了比较维生素B-12和全球DNA甲基化在小动物精子不育男性与肥沃的对照.
主要方法:
- 横截面研究涉及17个小种不育的雄性和10个健康的肥沃的雄性.
- 血清维生素B-12通过化学发光测量;使用ELISA评估全球DNA甲基化.
- 全球DNA甲基化水平与甲基化DNA控制相对量化.
主要成果:
- 与对照人群相比,不孕男性的血清维生素B-12平均水平显著降低.
- 类精子男性的全球DNA甲基化水平略低,但这种差异在统计学上并不显著.
- 在血清维生素B-12和甲基化缺陷之间观察到一个弱且在统计学上无意义的正相关性 (r=0.14).
结论:
- 与肥沃的对照人群相比,Oligozoospermic不育的雄性表现出显著的维生素B-12缺乏.
- 两组之间没有发现全球DNA甲基化的显著差异.
- 这项研究不支持血清维生素B-12水平与不育男性的全球DNA甲基化之间的相关性.
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