疾病修饰治疗的有意义的益处:评估与健康有关的资源使用变化
Carolyn W Zhu1,2,3, Mary Sano2,3
1Brookdale Department of Geriatrics and Palliative Medicine Icahn School of Medicine at Mount Sinai New York New York USA.
Alzheimer's & dementia (New York, N. Y.)
|August 1, 2024
概括
新的阿尔茨海默病治疗方法减缓了下降速度,对工作能力和非正式护理需求产生了积极影响. 这些对患者和家人至关重要的好处通常不会被标准的医疗记录所捕获.
科学领域:
- 神经学 神经学
- 卫生经济学 卫生经济学
背景情况:
- 新的疾病修饰疗法 (DMT) 具有减缓阿尔茨海默病 (AD) 进展的潜力.
- 评估这些治疗效应对患者福祉和资源利用的意义至关重要.
研究的目的:
- 确定早期阿尔茨海默病 (AD) 衰退率的减少是否反映在与健康相关的资源使用变化中.
- 评估疾病进展对非正式护理需求和工作能力的影响.
主要方法:
- 该研究包括了轻度认知障碍或轻度AD (CDR = 0.5或1) 的患者.
- 通过资源使用目录 (RUI) 评估了与健康相关的资源使用,包括直接医疗保健,非医疗保健,非正式护理和时间使用.
主要成果:
- CDR-Sum of Boxes (CDR-SB) 的较快下降与非正式照顾的增加以及就业/志愿者工作的可能性降低相关.
- 在CDR-SB下降和直接医疗保健利用 (例如住院治疗,医生访问) 之间没有发现显著的关联.
结论:
- 与DMT相比,CDR-SB的下降速度较慢,显著影响患者的工作能力和非正式护理需求.
- 这些影响对患者,家庭和卫生系统产生了重大的经济影响.
- 当前的行政数据往往无法捕捉到这些关键的资源利用变化,需要直接测量非正式的护理和劳动力.
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