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比较唐氏综合征和非唐氏综合征研究决策者的研究态度

Thuy V Lu^1,2, Paola Campos³, Sean Leader⁴

¹Department of Statistics University of California, Irvine Irvine California USA.

Alzheimer's & dementia (New York, N. Y.)

|August 1, 2024

概括

对于有唐氏综合征 (DS) 和没有唐氏综合征 (DS) 个体的决策者之间,研究态度平均相似. 然而,发现了特定的项目级别的态度差异,为DS研究提供了有针对性的招聘策略.

科学领域:

临床研究临床研究
唐氏综合征研究唐氏综合征研究
健康公平卫生公平

背景情况:

招聘挑战可能会阻碍研究进展,并引入涉及唐氏综合征 (DS) 患者和没有唐氏综合征 (DS) 患者的研究中的偏见.
了解决策者的态度对于有效的参与者招聘至关重要.
这项研究的目的是确定和量化决策者之间的研究态度的差异,对于有和没有DS的人来说.

研究的目的:

为了比较总体和项目级别的研究态度,对于唐氏综合征 (DS) 和没有DS的个体的决策者之间.
为参与不同人群的临床研究制定有针对性的招聘策略提供信息.

主要方法:

来自两个注册表的数据分析:加州大学欧文分校的C2C注册表 (非DS决策者) 和DS-Connect (DS家族决策者,不包括DS患者).
研究态度问卷 (RAQ) 总得分的比较使用线性回归.
评估物品级别的RAQ差异,使用比例概率回归,调整人口因素和COVID-19时间框架.

主要成果:

在调整后,在DS和非DS决策者之间的平均总RAQ分数中没有发现统计学上显著的差异.
对于患有DS的个人来说,决策者在帮助他人的责任方面表现出更好的回应率 (OR = 1.26).
对于DS患者的决策者,他们认为医学研究将在他们的一生中找到主要疾病的治疗方法,因此获得有利反应的几率降低了 (OR = 0.77).

结论:

对于患有唐氏综合征 (DS) 的人和不患有唐氏综合征 (DS) 的人,决策者之间的整体研究态度是可比的.
态度存在显著的物品级别差异,特别是在利他主义和对研究治疗的信念方面.
这些发现强调了需要量身定制的招聘策略,以加强DS患者群体的研究参与.

关键词:

唐氏综合征是什么意思唐氏综合征研究态度问卷调查问卷临床试验是指临床试验中的临床试验.研究态度研究态度研究态度研究登记册研究登记册

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