在泰国患有结直肠息肉的患者中,明显的肠道微生物组
Thoranin Intarajak1,2,3, Wandee Udomchaiprasertkul4, Ahmad Nuruddin Khoiri2
1Bioinformatics Unit, Chulabhorn Royal Academy, Lak Si 10210, Bangkok, Thailand.
World journal of gastroenterology
|August 1, 2024
概括
这项研究揭示了超塑性息肉 (HP) 和传统腺瘤 (TA) 中明显的肠道微生物群特征,突出了特定的细菌物种和参与结直肠息肉发育和致癌的代谢途径.
科学领域:
- 微生物组研究的研究.
- 胃肠道瘤学 胃肠道瘤学
- 分子生物学分子生物学
背景情况:
- 结肠直肠多,包括管状腺瘤 (TA) 和超塑性多 (HP),与肠道微生物组的改变有关.
- 与传统的腺瘤 - 癌瘤序列 (TA) 相比,对微生物组在状聚 (HP) 途径中的作用的理解是有限的.
- 调查HP和TA相关的微生物组变化可以阐明结直肠癌发生的机制.
研究的目的:
- 调查肠道微生物群的特征,微生物的关联,和微生物的功能,在患有高塑性息肉 (HP) 和传统腺瘤 (TA) 的患者.
主要方法:
- 16S rRNA测序用于分析来自40个对照组,52名HP患者和60名TA患者的便样本.
- 采用了差异丰度,并发网络和差异途径分析.
- 在不同组之间比较了微生物组组成和功能机制.
主要成果:
- TA患者显示CRC相关的细菌 (例如, *Streptococcus gallolyticus*) 和二次代谢物生物合成中的途径.
- HP患者在硫氧化途径中表现出丰富.
- *Mediterraneibacter gnavus* 在HP和TA组中均有差异性丰富.
- HP患者同时出现了与失生症相关的细菌,而TA患者患有与CRC相关的细菌;SCFA产生细菌在TA患者中较少见.
结论:
- 不同的肠道微生物组特征与不同的结肠直肠多胞体通路 (HP与TA) 有关.
- 特定的微生物物种,功能途径及其相互作用在结直肠癌发生过程中起作用.
- 研究结果通过不同的途径提供了对结直肠多发育背后的机制的见解.
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