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在患有白质超强度和认知功能的不匹配的患者中,动态功能网络连接.

Siyuan Zeng1, Lin Ma1, Haixia Mao1

  • 1Medical Imaging Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi People's Hospital, Wuxi, China.

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概括

在大脑小血管疾病 (CSVD) 中,动态功能网络连接 (dFNC) 分析揭示了白质超强度 (WMH) 和认知障碍患者的明显模式. 这些dFNC指标和潜在的成像特征的差异为认知不匹配机制提供了见解.

关键词:
解剖学 结构 结构 结构大脑小血管疾病是大脑小血管疾病.动态功能网络连接能力 动态功能网络连接定量分析量化分析静止状态的功能磁共振成像技术

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科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 认知神经科学 认知神经科学

背景情况:

  • 白质高强度 (WMH) 在脑小血管疾病 (CSVD) 中很常见,并与认知障碍有关.
  • 然而,WMH的严重程度并不总是与认知缺陷相关,这表明其他因素也参与其中.

研究的目的:

  • 调查认知匹配和不匹配的CSVD患者与WMH之间的动态功能网络连接 (dFNC) 的差异.
  • 量化探索CSVD认知不匹配的潜在机制.

主要方法:

  • 从149名CSVD患者获得休息状态功能磁共振成像 (rs-fMRI) 和认知评估.
  • 进行dFNC分析以获得指标,并将其与认知功能相关联.
  • 量化CSVD成像特征,包括周脉空间和中间叶缩 (MTA).

主要成果:

  • 对I型和II型CSVD的匹配和不匹配组之间观察到dFNC指标 (分数时间,平均停留时间) 的显著差异.
  • 与执行功能和处理速度相关的dFNC指标.
  • I型不匹配与周血管空间和MTA相关,而II型不匹配与MTA和教育年限相关.

结论:

  • 在CSVD中,I型认知不匹配与更高层次的网络变化有关,可能是由于周血管空间和大脑缩.
  • 二型不匹配涉及初级网络变化,可能与大脑缩和教育背景有关.