手术脱皮修改了痕信号,并可能改善局部先进的基底细胞癌的可视化有效性
Natella Maglakelidze1, Samantha L Gettle1, Amy L Longenecker1
1Department of Dermatology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
概括
在局部晚期基底细胞癌 (LaBCC) 治疗前进行手术,可能会改变瘤分子通路. 这种方法在一些患者中显示出临床反应,这表明在LaBCC治疗中改善结果的潜力.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 分子生物学分子生物学
背景情况:
- 维斯莫迪吉布对局部晚期的基底细胞癌 (LaBCC) 有效,但副作用限制了其使用.
- 在vismodegib之前的手术脱皮已经显示出在LaBCC中延长缓解的希望.
- 了解脱脂后的分子变化对于优化LaBCC治疗至关重要.
研究的目的:
- 为了评估LaBCC患者的临床结果,他们接受了脱皮治疗,随后接受了vismodegib.
- 在手术解封后分析LaBCC组织中的分子变化.
主要方法:
- 四名LaBCC患者接受了脱皮手术,随后进行了视莫迪吉布.
- 抽取残留瘤组织的穿孔活检是在卸载后一周收集的.
- 通过RT-qPCR,免疫斑块和免疫染色分析了Notch和Wnt信号通路.
主要成果:
- 在脱脂后观察到PTCH1,HEY2,LGR6,FZD2,LEF1,ALCAM和RUNX1基因的表达升高.
- 在后续活检中证实了痕信号的升高.
- 四分之三的患者对联合治疗有临床反应.
结论:
- 对LaBCC的手术操作与分子路径的改变有关.
- 这种组合治疗可能为LaBCC.提供一个可行的治疗策略.
- 需要进一步的研究来阐明手术诱导的细胞重编程机制.
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