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不同的胰腺切除对Suncus murinus的内分泌功能的影响范围不同
Ru-Jia Li1, Ting Yang1, Yu-Hao Zeng1
1Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo 116-8551, Japan.
World journal of gastrointestinal surgery
|August 1, 2024
概括
松鼠的胰腺切除会影响葡萄糖耐受性. 亚总胰腺切除术导致体重减轻和GLP-1增加,这表明胰腺激素在葡萄糖平衡中的作用.
科学领域:
- 内分泌学 在内分泌学.
- 手术研究的研究.
- 动物模型 动物模型
背景情况:
- 胰腺手术可能导致内分泌功能障碍和葡萄糖耐受性受损.
- 胰腺切除术的程度,特别是腹部胰腺的参与,影响了术后糖尿病风险.
- 在Suncus murinus中明显的腹腔和背部胰腺提供了一个研究切除效应的模型.
研究的目的:
- 为了评估不同胰腺切除范围对Suncus murinus内分泌功能的影响.
- 为了将手术范围与胰腺切除术后的代谢和荷尔蒙变化相关联.
主要方法:
- 雄性Suncus murinus接受了腹腔胰腺切除术 (VPx),部分胰腺切除术 (PPx),亚总胰腺切除术 (SPx) 或假冒手术.
- 测量包括食后血清胰岛素,GLP-1,PP,SST,食物摄入量,体重,血糖和葡萄糖耐受性.
主要成果:
- PPx和SPx诱导葡萄糖耐受性受损;SPx组的一个小部分发生了糖尿病.
- SPx导致食物摄入量减少,体重显著减轻,食后GLP-1增加.
- 在VPx和PPx组中,食后PP降低;在VPx和PPx组中,SST略有降低.
结论:
- 在广泛的胰腺切除术后,补偿性GLP-1升高可能会导致食欲丧失和体重减轻.
- 胰腺多 (PP) 和GLP-1似乎在减轻手术后血糖失衡方面发挥作用.
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