芬太尼和新型合成阿片类药物在意外过量死亡中的作用
Jihau Yu1, Katie Diekhans1, Anson Tsang1
1Office of the Chief Medical Examiner, San Francisco, CA 94124, United States.
Journal of analytical toxicology
|August 1, 2024
概括
新型合成阿片类药物 (NSO),特别是芬太尼,在旧金山过量死亡中越来越多地被检测到. 这项研究证实了它们向西海岸的迁移,突出了日益严重的公共卫生问题.
科学领域:
- 法医毒理学 法医毒理学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 新型合成阿片类药物 (NSO) 是快速扩大的精神活性物质类别.
- 美国注意到NSO检测的增加,但东海岸以外的数据很少.
- 芬太尼类似物 (fentalogs) 是一个重要的类别的NSO与类受体结合.
研究的目的:
- 确定2022年旧金山意外过量死亡中NSO,特别是芬的患病率.
- 分析生物标本和药物配件以检测NSO的存在.
- 为了记录芬太尼在西海岸的地理分布.
主要方法:
- 使用经过验证的液体染色学-并联质谱法 (LC-MS/MS) 方法分析了250多个NSO.
- 分析了617例意外过量死亡的血液和尿液样本.
- 检查了NSO存在的匹配药物器具.
主要成果:
- 在7.8% (617例中48例) 的分析病例中,至少检测到一个NSO.
- 在所有48个阳性病例中都存在 fentalogs,在40个病例中检测到fluorofentanyl.
- 芳的度在血液中的0.18.9 ng/mL和尿中的0.0585 ng/mL之间. 多种物质的使用是常见的.
结论:
- 这项研究证实了芳的存在和迁移到西海岸,特别是加利福尼亚.
- 在生物样本和药物用品中发现了NSO,主要是芬太尼.
- 这些发现强调了在西海岸需要扩大NSO监测和有针对性的公共卫生干预的必要性.
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