休时间 久坐不动的行为,体力活动和心血管疾病 在代谢功能障碍相关脂肪肝疾病的个体中
Hanzhang Wu1,2, Jiahe Wei1,2, Wenjuan Chen3
1Department of Big Data in Health Science, Zhejiang University School of Public Health and Sir Run Run Shaw Hospital (H.W., J.W., S.W., X.T.), Zhejiang University School of Medicine, Hangzhou, China.
较高的体力活动和较少的久坐行为显著降低了与代谢功能障碍相关的脂肪肝疾病患者的心血管疾病 (CVD) 风险. 通过体力活动取代久坐的时间始终可以减少心血管疾病的结果,无论遗传倾向如何.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是心血管疾病 (CVD) 的已知的危险因素.
- 了解身体活动和久坐不动行为等生活方式因素对于管理MAFLD患者心血管疾病风险至关重要.
- 对心血管疾病的遗传倾向可能与MAFLD的生活方式因素相互作用.
研究的目的:
- 评估休时间体育活动,久坐行为和MAFLD患者心血管疾病风险之间的关联.
- 调查静坐时间被体力活动所取代对心血管疾病风险的影响.
- 检查遗传倾向在这些关联中的作用.
主要方法:
- 来自英国生物库的157,794名MAFLD患者的大型队列研究,没有基线CVD.
- 通过频率和持续时间评估休时间的久坐行为 (电视,电脑,驾驶) 和体育活动 (散步,体育,DIY).
- 利用考克斯的比例危险和同时代替代模型来分析心血管疾病风险.
主要成果:
- 较高的体力活动与显著降低心血管疾病 (21%),冠心病 (20%),中风 (15%) 和心力衰竭 (31%) 的风险相关.
- 与较低的静坐时间 (≤3.5小时/天) 相比,增加的静坐行为 (>6.5小时/天) 与16-21%更高的心脏病结局风险有关.
- 将30分钟的静坐时间替换为体育活动,可以将心血管疾病风险降低3-16%,而艰苦的运动显示出最大的益处. 对于中风风险,发现了身体活动,久坐行为和遗传倾向之间的显著相互作用.
结论:
- 休时间增加的体力活动与MAFLD患者心血管疾病风险降低有关.
- 增加的久坐行为与此种人群中心血管事件的风险更高有关.
- 将静坐时间替换为体力活动为减少心血管疾病的结果提供了一致的好处,独立于遗传风险.
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