在唐氏综合征中白质超强度的特征
Alejandra O Morcillo-Nieto1, Sara E Zsadanyi1, Jose E Arriola-Infante1
1Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
概括
白质超强度 (WMHs) 在阿尔茨海默氏症 (AD) 症状在唐氏综合征 (DS) 症状出现10年前出现. 这些WMH与AD生物标志物和神经退行有关,这表明它们在AD病理生理学中发挥了直接作用.
科学领域:
- 神经成像是一种神经成像.
- 神经退行性疾病 神经退行性疾病
- 遗传学 遗传学 是一个
背景情况:
- 白质高强度 (WMHs) 在唐氏综合征 (DS) 中很常见.
- 它们的具体位置和与阿尔茨海默病 (AD) 生物标志物的联系尚未得到充分了解.
- 这项研究研究了DS中的WMH地形及其与AD病理学的关联.
研究的目的:
- 探索成年人DS的WMH的地形分布.
- 检查WMHs,社会人口因素和阿尔茨海默病生物标志物之间的关系.
- 为了理解WMH与灰色物质体积在DS中的关联.
主要方法:
- 261名患有DS的成年人和131名euploid对照人接受了MRI扫描.
- WMHs被细分为白质层和叶片区域.
- 分析了与AD阶段,人口统计,CSF生物标志物和灰质体积的关联.
主要成果:
- 在DS中,WMHs出现在43岁左右,随着年龄的增长而增加.
- 随着AD连续性,WMH体积上升,特别是在周腹和叶片区域.
- 在WMHs,CSF生物标志物和temporo-parietal灰色物质体积之间发现了显著的关联.
结论:
- 在DS中,在AD症状出现前10年,WMH显著增加.
- WMH与AD生物标志物密切相关,包括神经丝光链.
- 这些发现表明,WMHs是DS中AD病理生理学的组成部分,独立于血管因素.
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