超越肠道:内微生物对瘤发生和治疗反应的影响
Hao Zhang1, Li Fu1,2, Xinwen Leiliang1
1Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, P. R. China.
Cancer communications (London, England)
|August 1, 2024
概括
瘤内微生物群 (TM),瘤内的微生物,影响癌症的发展和治疗反应. 了解TM的起源,机制和治疗应用对于推进癌症治疗至关重要.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 癌症研究 癌症研究
背景情况:
- 内微生物群 (TM) 包含瘤组织内的微生物,与肠道或循环微生物群不同.
- TM在瘤发生,癌症进展,转移和治疗结果方面发挥着重要作用.
研究的目的:
- 审查当前对内微生物组的理解.
- 探索TM的起源,分析技术,癌症中的作用机制和治疗潜力.
主要方法:
- 关于内微生物组研究的综合文献综述.
- 关于TM分析的先进技术的总结.
- 对TM在癌症进展和治疗策略中的作用的分析.
主要成果:
- 确定了通道来源,相邻的正常组织,循环系统和共转移作为主要TM来源.
- TM影响癌症的详细机制,包括DNA损伤,致癌途径 (PI3K,STAT,WNT/β-catenin,ERK),炎症和瘤微环境相互作用.
- 突出了TM通过代谢物和免疫细胞调节对抗瘤和促瘤免疫的参与.
结论:
- TM是癌症发展和进展的关键因素,提供了新的治疗点.
- 先进的分析技术和对TM机制的更深入理解正在为创新的癌症治疗铺平道路.
- 未来的方向包括免疫疗法,化疗,放射疗法,基于微生物组的疗法 (益生菌,FMT,工程微生物群),菌体疗法和瘤病毒,尽管临床挑战.
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