双A及其类似物与大西洋鱼 (Gadus morhua) 的雌激素和雄激素受体的相互作用
Siri Øfsthus Gokso Yr1, Fekadu Yadetie1, Christine Tveiten Johansen1
1Department of Biological Sciences, University of Bergen, Bergen N-5020, Norway.
Environmental science & technology
|August 1, 2024
概括
双A (BPA) 和它的类似物是水生生态系统中的内分泌干扰物. 即使是BPA替代品也表现出雌激素和抗雄激素作用,对野生动物和潜在的人类健康构成风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 双A (BPA) 是水生生态系统中广泛存在的环境污染物.
- 众所周知,BPA对野生动物具有内分泌干扰作用.
- 对BPA的担忧导致使用替代双化合物.
研究的目的:
- 调查BPA和11种类型的雌激素,抗雌激素,抗和抗效应.
- 评估这些化合物对雌激素和雄激素受体信号通路的影响.
- 评估BPA替代品在水生生物中的内分泌干扰潜力.
主要方法:
- 使用了体外记者基因测试.
- 使用了来自大西洋鱼 (Gadus morhua) 的精确切割肝脏切片.
- 研究了大西洋鱼雌激素受体α (gmEra) 和雄激素受体α (gmAra) 的激活和抑制.
主要成果:
- 大多数双,包括BPA,激活了gmEra,显示出雌激素性质.
- 一些类似物,如BPB,BPE和BPF,显示效果与BPA相等或更高.
- 一些双通过生物转化诱导肝脏切片中的雌激素作用,以及一些表现出抗雄激素活性.
结论:
- 双,包括BPA替代品,对水生生物有显著的内分泌干扰作用.
- BPA的替代品可能对环境和人类健康构成同等或更大的风险.
- 需要进一步的研究,以了解双相似物对内分泌系统的全部影响.
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