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Published on: December 22, 2016
氧储量指数与常规的外周氧和用于预防低氧化症:一项随机对照试验
Eun-Hee Kim1, Jung-Bin Park, Pyoyoon Kang
1From the Department of Anaesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea (E-HK, J-BP, PK, S-HJ, Y-EJ, J-HL, H-SK, J-TK).
监测氧储量指数 (ORI) 在儿科喉微手术期间没有降低低氧和 (SpO2 ≤ 90%) 的发生率. 然而,ORI监测与每位患者的严重低氧事件较少相关.
科学领域:
- 麻醉学和外科手术期间的医学.
- 儿科手术 儿科手术
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 低氧症是儿科喉微手术中经常出现的并发症.
- 氧储量指数 (ORI) 是评估氧化的非侵入性参数,在100-200 mmHg PaO2范围内特别有用.
研究的目的:
- 调查氧气储备指数 (ORI) 的监测是否可以在儿科喉微手术期间降低 SpO2 ≤ 90% 的发生率.
- 评估ORI监测作为标准脉冲氧计辅助的有效性,以预防低氧化.
主要方法:
- 在第三级护理儿科医院进行的随机对照试验.
- 接受喉微手术的儿科患者 (≤18岁) 被随机分配到ORI监测组或对照组.
- 救援干预是由ORI≤0.2或SpO2≤94% (对照组) 触发的.
主要成果:
- 在ORI和对照组之间,SpO2≤90%的发病率没有显著差异 (25%与40.9%,P=0.114).
- 然而,与对照组相比,ORI组 (中位数0) 的每位患者 SpO2 ≤ 90% 事件的数量明显低于对照组 (中位数0,P=0.031).
- 虽然严重低氧症的总体发病率没有降低,但ORI组每名患者的严重低氧事件较少.
结论:
- 目标值>0.2的氧储量指数 (ORI) 的额外监测没有降低小儿呼吸道手术期间SPO2 ≤90%的初级结果.
- 尽管没有达到主要终点,但ORI监测与每位患者严重低血量事件的频率减少有关.
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