婴儿时期的简单疹病毒:评估国家监视病例捕获情况
Angela Berkhout1,2,3, Daniel K Yeoh4,5,6, Suzy Teutsch3,7
1Infection Management and Prevention Service, The Queensland Children's Hospital, Brisbane, Queensland, Australia.
Journal of paediatrics and child health
|August 1, 2024
概括
澳大利亚儿科监测单位 (APSU) 的监测捕获了三分之一的婴儿简单疹病毒 (HSV) 病例,特别是严重的病例. 综合实验室和监测数据对于理解和改善这种严重感染的结果至关重要.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 公共卫生监督 公共卫生监督
背景情况:
- 婴儿时的简单疹病毒 (HSV) 是一种严重的疾病.
- 在澳大利亚,在婴儿监测中确定HSV的完整性一直是个挑战,因为它不是一个强制性通报条件.
- 澳大利亚儿科监测单位 (APSU) 旨在追踪这种情况.
研究的目的:
- 评估昆士兰州 (QLD) 和西澳大利亚州 (WA) 婴儿HSV感染病例捕获的完整性.
- 将APSU的数据与全州实验室和临床记录进行比较.
- 评估积极监测在识别婴儿HSV病例方面的有效性.
主要方法:
- 在2007年至2017年期间,从QLD和WA公共病理学提供商获得的婴儿 (0-3个月) 中使用了HSV聚合酶链反应 (PCR) 阳性结果.
- 从患者记录中提取并比较临床数据与向APSU报告的病例.
- 分析了实验室确定的病例和监测报告的病例之间的重叠和差异.
主要成果:
- 通过实验室数据识别了94例婴儿HSV病例 (70 QLD,24 WA) 与36例报告给APSU (26 QLD,10 WA).
- 总的来说,确定了102个独特的病例;积极监控捕获了所有病例的35% (36/102).
- 监测发现了较高比例的严重病例:中枢神经系统 (CNS) 疾病的74%,传播疾病的71%,而皮肤,眼睛和口腔 (SEM) 疾病的17%.
结论:
- APSU的积极监测捕获了严重婴儿HSV病例的很大一部分,但整体上错过了大多数.
- 尽管有监测工作,婴儿HSV发病率和死亡率仍然很高.
- 使用联合实验室和监测数据进行增强的病例确定对于未来的HSV研究和改善患者结果至关重要.
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