人类牛奶对全球病原体的抗体揭示了IgA和IgG的地理和个体间变异
Joseph J Campo1, Antti E Seppo2, Arlo Z Randall1
1Antigen Discovery Incorporated, Irvine, California, USA.
The Journal of clinical investigation
|August 1, 2024
概括
人类牛奶抗体因地理位置而异,南亚的抗体水平较高. 母亲因素,如BMI和平价影响抗体度,影响婴儿对病原体的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 高通量技术促进了对宿主对病原体的免疫反应的理解.
- 母乳含有对婴儿免疫力至关重要的抗体.
- 病原体暴露的全球变化会影响牛奶抗体概况.
研究的目的:
- 为了比较不同经济和地理位置的人类牛奶抗体对传染病原体的谱,保护和孕产妇因素.
- 调查母亲特征与牛奶抗体水平之间的关系.
- 评估牛奶抗体对婴儿特定感染的保护作用.
主要方法:
- 分析了来自5个国家 (孟加拉国,芬兰,秘鲁,巴基斯坦,美国) 的695名妇女的878个牛奶和94个配对血清样本.
- 利用多病原体蛋白质微阵列来评估针对30种病原体的1607种蛋白质的特定IgA和IgG抗体.
- 收集有关母亲因素的数据,包括身体质量指数 (BMI) 和均值.
主要成果:
- 对肠道和呼吸道病原体的抗体覆盖率在孟加拉国和巴基斯坦最高,在美国和芬兰最低.
- 病原体特异性抗体反应各不相同,其中一些诱导主导IgA,另一些诱导IgA和IgG.
- 在高BMI (IgA) 和高平价 (IgG) 的母亲中观察到较低的牛奶抗体度.
- 较高的牛奶IgA对抗轮状病毒与孟加拉国婴儿的延迟感染相关;较高的IgA对抗Campylobacter与感染发生率增加相关.
结论:
- 人类母乳抗体概况表现出显著的地理和经济差异.
- 像BMI和平价等母亲因素与牛奶抗体度有关.
- 了解牛奶抗体动态对于开发被动免疫策略以减少婴儿发病率和死亡率至关重要.
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