产前维生素E水平与儿童喘和喘息有关
Terryl J Hartman1, Tebeb Gebretsadik2, Margaret A Adgent3,4
1Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
母亲的维生素E异构体 (α和gamma-tocopherol) 与儿童喘没有显著的关联. 然而,母亲喘病史可能会改变阿尔法托科菲罗尔对儿童喘风险的影响.
科学领域:
- 营养流行病学 营养流行病学
- 环境健康 环境健康
- 儿童呼吸系统健康问题
背景情况:
- 产前暴露于维生素E异构体,α-托科菲罗和-托科菲罗,正在研究其在儿童喘和喘息中的潜在作用.
- 了解这些关联对于公共卫生倡议和生命早期干预至关重要.
研究的目的:
- 检查母体血α-托科菲罗尔和gamma-托科菲罗尔水平对8-9岁儿童喘和喘息的个体和相互作用影响.
- 在这些关系中识别潜在的改变因素,如母亲喘病史.
主要方法:
- 这项研究利用了影响神经认知发育和早期儿童学习的条件 (CANDLE) 产前队列的数据 (n=847 dyads).
- 分析了母亲的第二个三个月的血样本,以检测托科费罗尔和脂质度.
- 用验证的问卷进行了儿童喘和喘息的评估,并使用多变量逻辑回归来分析关联和相互作用.
主要成果:
- 没有发现母亲的α-托科菲罗尔或玛-托科菲罗尔水平与儿童喘或喘息之间有统计学意义的关联.
- 虽然在统计学上不显著,但观察到对α-托科菲罗尔的反向关联和对玛-托科菲罗尔的积极关联与喘结果.
- 一个显著的相互作用 (p=0.05) 表明,母亲喘病史可能会改变母亲阿尔法-托科菲罗和儿童喘之间的关联.
结论:
- 在这个队列中,对alpha-tocopherol和gamma-tocopherol的产前暴露与儿童喘或喘息没有显著联系.
- 孕产妇喘病史可能在修改孕产妇阿尔法托哥菲罗尔水平与儿童喘风险之间的关系方面发挥作用.
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