托法西提尼布暴露不会增加性结肠炎患者的术后并发症 接受全肠切除术:一项回顾性病例对照研究
Ibrahim Gomaa1, Sara Aboelmaaty1, Himani Bhatt1
1Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota.
Diseases of the colon and rectum
|August 1, 2024
概括
在手术前暴露于托法西替尼,并没有增加静脉血栓塞栓症或其他术后并发症,而性结肠炎患者接受了切除术. 这项回顾性研究发现,托法西提尼布暴露和未暴露患者之间的结果没有显著差异.
科学领域:
- 胃肠病学和外科手术
- 药理学和治疗学 药理学和治疗学
- 血栓形成和血液静止.
背景情况:
- 性结肠炎,全肠切除术和托法西替尼都与静脉血栓塞栓症 (VTE) 的风险增加有关.
- 术前使用托法西提尼布对VTE风险和术后并发症在性结肠炎患者进行大肠切除术的潜在影响仍然是一个重要的临床问题.
研究的目的:
- 调查手术前托法西提尼布暴露是否会增加静脉血栓栓塞 (VTE) 或其他术后并发症的风险.
- 为了比较性结肠炎患者的结局,这些患者接受了亚总结肠切除术,总结肠切除术或总结肠切除术,并没有最近接触托法西提尼布.
主要方法:
- 在一个单一的第三级推中心进行了一项回顾性,病例对照性研究.
- 成年性结肠炎患者 (n=56) 在2018年后接受托法西提尼布在30天内切除 (部分,全部或全部切除) 后,与没有托法西提尼布暴露的匹配对照组 (n=56) 相比.
- 主要结局:90天内VTE发生率. 二次结果:90天的术后并发症.
主要成果:
- 暴露于托法西替尼布和未暴露的组在年龄和性别方面匹配得很好.
- 虽然生物药物暴露有所不同 (36%与66%),但调整后的分析显示,两组之间在VTE发生率 (4%与14%,p=0.09) 或其他术后并发症方面没有统计学上显著的差异.
- 大多数患者在出院后接受了延长的VTE预防.
结论:
- 在这项回顾性单一机构研究中,手术前对托法西提尼布的暴露与性结血栓塞或其他术后并发症的风险增加没有关联,而是在接受大肠切除术或直肠切除术的性结肠炎患者中.
- 研究结果表明,在等待进一步调查之前,在重大腹部手术之前,托法西提尼布可以在这个患者群体中安全地使用.
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