巴西的鼻息病患者慢性鼻炎的炎症概况:多中心研究
Fabrizio R Romano1, Fabiana C P Valera2, Marco A Fornazieri3
1Department of Ophtalmology, Otorhinolaryngology and Head and Neck Surgery, University of Sao Paulo, FMRP-USP, São Paulo, Brazil.
概括
这项研究在巴西患者中发现了两种不同的炎症概况,这些患者患有鼻息肉 (CRSwNP) 的慢性鼻炎. 鼻息肉中43个埃索诺菲尔/HPF的值可以区分这些CRSwNP亚组.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 病理学 病理学 病理学
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 是一种复杂的炎症状况,具有多种临床表现.
- 了解CRSwNP的炎症概况对于有针对性的治疗策略至关重要.
- 以前的研究表明,在CRSwNP种群中存在不同的炎症内型.
研究的目的:
- 为了确定巴西CRSwNP的炎症概况.
- 用基于炎症标志物的集群分析来描述CRSwNP患者子组.
- 研究巴西CRSwNP患者的炎症标志物和临床特征之间的关系.
主要方法:
- 在巴西的15个中心进行了一项多中心,横截面的研究.
- 从166名CRSwNP患者和80名对照组中收集了临床数据,包括人口统计,并发病情况和内镜/CT评分.
- 分析了鼻多样本以检测埃索诺菲尔和中性粒细胞的数量以及细胞因子度.
主要成果:
- 与对照组相比,CRSwNP患者的细胞因子水平显著变化,包括IFN-gamma高,TNF-alpha低.
- 集群分析揭示了基于细胞因子度的两个不同的CRSwNP组,其中集群1显示了更高的整体细胞因子水平.
- 鼻息肉中43或以上的乙氨基基/乙氨基切割值有效地区分了这两个群体,与较高的隆德-麦凯分数和男性患病率相关.
结论:
- 巴西的CRSwNP患者表现出混合的炎症模式.
- 确定了两个不同的炎症子组,其特点是炎症标志物高和低.
- 组织乙素 (≥43个乙素/HPF) 作为一个可靠的生物标志物来区分这些CRSwNP亚组.
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