在患有脑瘤的患者中,后部语言区域的功能更广泛
Riho Nakajima1, Takahiro Osada2, Masashi Kinoshita3
1Department of Occupational Therapy, Faculty of Health Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Human brain mapping
|August 1, 2024
概括
在大脑中的皮层重组.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 脑部成像 脑部成像
背景情况:
- 对后部语言区域 (PLA) 或韦尼克区域的损伤导致大脑重组.
- 了解半球半侧半球内的重组仍然不完整.
- 直接电刺激提供了对大脑神经调节的独特的体内洞察力.
研究的目的:
- 为了研究后面语言区域 (PLA) 的 ipsilateral半球内皮质重组的特征.
- 探索影响PLA的质瘤患者的语言网络可塑性.
主要方法:
- 在62名左半球质瘤患者的清醒手术期间直接皮质刺激.
- 图片命名任务用于评估刺激期间的语言功能.
- 休息状态功能磁共振成像 (fMRI) 和功能连接性分析,包括中间中心性,在一组患者中.
主要成果:
- 非PLA患者的积极刺激反应主要发生在后上旋 (pSTG) 中.
- 在PLA患者中,积极的反应从pSTG扩展到后部上边脊髓 (pSMG).
- 在pSMG中,PLA组 (47%) 与非PLA组 (8%) 的积极反应显著增加,并被确定为一个高度相互关联的中心区域.
结论:
- 语言处理可以超越PLA扩展到pSMG,这是一个关键的网络枢纽,特别是当PLA受到损伤进展的影响时.
- 在pSMG中这种扩展的语言表现可能作为一种补偿机制,以保持高效的大脑网络功能.
- 这些发现突出了语言网络的动态性质和它们在脑损伤后的重组能力.
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