甲状腺差异化得分与乳头甲状腺癌生存结果之间的关联
Jennifer R Wang1,2, Mark E Zafereo1, Maria E Cabanillas3
1Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
The Journal of clinical endocrinology and metabolism
|August 1, 2024
概括
甲状腺差异化评分 (TDS) 可以预测皮肤状甲状腺癌 (PTC) 的存活率. 更高的TDS与更长的无进展生存时间有关,特别是在BRAFV600E突变的PTC中.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 基因组学就是基因组学.
背景情况:
- 乳头甲状腺癌 (PTC) 的分化对预后至关重要.
- 甲状腺分化评分 (TDS) 使用16个基因mRNA水平量化分化.
- 在PTC中,TDS具有作为预后标记物的潜力.
研究的目的:
- 调查PTC患者TDS和生存结果之间的关联.
- 通过独立患者队伍验证TDS作为预后生物标志物.
主要方法:
- 利用了两个独立的PTC队列:癌症基因组图谱 (TCGA) 和MD安德森癌症中心 (MDACC).
- 评估无进展间隔 (PFI) 和整体存活期 (OS) 作为主要结局.
- 用Kaplan-Meier和Cox的比例危险模型进行生存分析.
主要成果:
- 在两个队列中,TDS与瘤/结节阶段和驱动突变状态相关.
- 在单变量分析中,较高的TDS与较长的PFI有关.
- 在调整阶段后,TDS仍然是MDACC队列中PFI的显著预测因子,尤其是在BRAFV600E突变瘤中.
结论:
- 在PTC中,TDS有效量化了差异化状态.
- 作为预后生物标志物,TDS显得有前途,特别是对于BRAFV600E突变的PTC.
- 进一步验证可能会在PTC患者的临床决策中建立TDS.
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