爱尔兰旅行者的功能衰竭
Paul O'Hara1, Husam Alzayer2,3, Luke Harris4
1Department of Nephrology, Galway University Hospitals, Galway, Ireland. paul.ohara4@hse.ie.
Irish journal of medical science
|August 1, 2024
概括
与一般人群相比,爱尔兰旅行者显示功能衰竭需要替代疗法 (KFRT) 的患病率与一般人群相似. 他们很快就能获得治疗,但不太可能使用家庭疗法,与移植等待时间相比.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在爱尔兰旅行者群体中发生功能衰竭与替代疗法 (KFRT) 的情况没有得到充分证实.
- 本研究调查了这个特定的人群中KFRT和相关健康决定因素的负担.
- 了解这些因素对于公平的医疗保健服务至关重要.
研究的目的:
- 为了确定爱尔兰旅行者中KFRT的流行率.
- 确定影响该群体中KFRT的人口和临床因素.
- 为了将KFRT的特征与爱尔兰普通人口进行比较.
主要方法:
- 自认爱尔兰旅行者与KFRT (1995-2022) 的回顾性队列研究.
- 数据来源于国家病临床患者管理系统.
- 主要结局:KFRT患病率;次要结局:诊断时的年龄,KRT方式,移植时间.
主要成果:
- 在爱尔兰旅行者中观察到0.12% (11.9/10,000) 的粗略KFRT患病率.
- 诊断时的平均年龄为43岁;KRT启动时的平均年龄为45岁.
- 血液透析是占主导地位的KRT (89%),中央静脉导管很常见 (79%); 45%接受了移植,平均等待时间为1.96年.
结论:
- 爱尔兰旅行者表现出的KFRT患病率与全国平均水平相当.
- 在诊断和KRT启动之间存在很短的间隔.
- 家庭疗法使用率较低,但脏移植等待时间与全国平均水平相似.
相关概念视频
Dialysis
286
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
286
Renal Failure: Dose Adjustments
77
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
77
Factors Affecting Renal Clearance: Renal Impairment
69
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
69
Regulation of Water Intake
489
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
489
Heart Failure Drugs: Diuretics
355
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
355
Nephrons
2.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.3K


